Como a amitriptilina pode ajudar as pessoas com fibromialgia

Por:   WYATT REDD

Ao longo dos anos, vários medicamentos passaram por avaliação para uso no tratamento da fibromialgia. Esses medicamentos incluem relaxantes musculares, corticosteróides, medicamentos anti-inflamatórios não esteroidais (AINEs), sedativos e antidepressivos tricíclicos.

Antidepressivos tricíclicos na verdade têm alguma história no tratamento da fibromialgia. De fato, vários desses antidepressivos são usados ​​no tratamento da doença. Nortriptilina, doxepina e amitriptilina são todos utilizados no tratamento da fibromialgia. Quando usado para fibromialgia, em particular, tem sido demonstrado em estudos para ser o antidepressivo mais eficiente para o tratamento da doença.

Sobre amitriptilina para fibromialgia

Amitriptilina é, como mencionado, um tipo de antidepressivo tricíclico (TCA) usado no tratamento da depressão clínica. Como resultado, é considerado o TCA mais comum usado em todo o mundo.

O antidepressivo foi originalmente desenvolvido pela Merck e foi sintetizado pela primeira vez em 1960. Mais tarde, foi aprovado pela Food and Drug Administration em abril de 1961.

Este medicamento funciona como um inibidor dos serotonina e norepinefrina. O mecanismo de ação da medicação atua fortemente no transportador de serotonina, enquanto causa um efeito moderado no transportador de norepinefrina. Não faz nada para afetar o transportador de dopamina, no entanto.

Amitriptilina é usada para várias condições médicas, incluindo seu uso aprovado pela FDA para transtorno depressivo maior. Isso não impede que outros recursos médicos afirmem que ele desempenha um papel na assistência à recuperação de outras condições semelhantes.

Diz-se que a amitriptilina atua de forma mais eficiente que outros antidepressivos no tratamento de distúrbios. Curiosamente, é realmente passado por outros antidepressivos mais recentes, uma vez que é conhecido por causar efeitos colaterais e pode ficar muito tóxico se consumido para overdose.

Antidepressivos e fibromialgia

Vários medicamentos são usados ​​para tratar os sintomas da fibromialgia. Os medicamentos mais comuns incluem analgésicos, pílulas para dormir e vários antidepressivos. Dizem que os antidepressivos ajudam a tratar os  sintomas da fibromialgia originados da disfunção das funções normais do cérebro .

Antidepressivos, especialmente antidepressivos tricíclicos, têm sido usados ​​no tratamento da fibromialgia há anos. Os antidepressivos tricíclicos são, na verdade, alguns dos antidepressivos mais antigos no mercado e têm sido utilizados em tratamentos de fibromialgia há anos.

Os antidepressivos tricíclicos, como a amitriptilina, aumentam os níveis de substâncias químicas ou neurotransmissores do cérebro. Quando os níveis de neurotransmissores são impulsionados, evita que o cérebro sucumba ao comprometimento de sua função natural. Estes antidepressivos impulsionam principalmente a serotonina e norepinefrina dos neurotransmissores. Depois de tomar esses antidepressivos, as pessoas com dor crônica geralmente se sentem muito melhor, pois são conhecidas por terem níveis mais baixos dos neurotransmissores acima mencionados presentes em seu cérebro.

Antidepressivos tricíclicos também desempenham um papel em ajudar a relaxar os músculos cheios de dor. Também aumenta o analgésico natural do corpo, também conhecido como endorfinas. Mesmo que esses medicamentos tenham resultados positivos para condições como fibromialgia, eles têm vários efeitos colaterais que podem torná-los difíceis de tomar em uma base regular.

Curiosamente, os antidepressivos tricíclicos prescritos para a fibromialgia incluem duloxetina, milnaciprano e venlafaxina. Tanto a duloxetina como o milnaciprano já estão aprovados pela Food and Drug Administration para o tratamento da fibromialgia.

A venlafaxina tem menos pesquisas e, portanto, evidências que a apoiam como um tratamento eficaz. Outros antidepressivos que foram estudados e propostos como potenciais tratamentos para fibromialgia incluem citalopram, paroxetina e fluoxetina.

Amitriptilina se enquadra na categoria de antidepressivos tricíclicos não testados relativos sem mais apoio como tratamento de fibromialgia. No entanto, isso não impediu os pesquisadores de estudá-lo e seu potencial como um tratamento eficaz para a fibromialgia.

Estudos sobre amitriptilina

Os antidepressivos têm sido usados ​​para tratar distúrbios da dor crônica por anos. Embora isso seja verdade, existe apenas uma quantidade limitada de estudos sobre como os antidepressivos tricíclicos ajudam as pessoas a tratar seus sintomas de fibromialgia.

De acordo com informações coletadas sobre fibromialgia e antidepressivos, os antidepressivos, como os antidepressivos tricíclicos, produziram melhora de leve a moderada nos sintomas da fibromialgia. Em estudos controlados, verificou-se que tanto quanto um terço a metade dos pacientes monitorados responderam ao tratamento baseado em medicação.

Houve um estudo que testou os efeitos da amitriptilina e fluoxetina em pacientes com fibromialgia. Os pacientes nesse estudo receberam 25 mg de amitriptilina, enquanto outros receberam 20 mg de fluoxetina.

Como resultado, os pacientes descobriram que qualquer medicamento ajudou a reduzir os sintomas da fibromialgia. Os pacientes que tomaram os dois medicamentos descobriram que a combinação era, na verdade, “duas vezes mais eficaz” do que apenas tomar um medicamento sozinho.

As dosagens usadas para a amitriptilina para fibromialgia são muito mais baixas do que as doses usuais para o tratamento da depressão. Na maioria dos casos, a dose pode ser iniciada com uma dose tão baixa quanto 10 mg por dia, tomada 2 a 3 horas antes de dormir. Isso permite que o paciente aproveite os efeitos sedativos da medicação sem experimentar os mesmos efeitos quando acordado.

Resultado de imagem para Amitriptilina

Outro estudo de amitriptilina acompanhou 70 pacientes diferentes com a doença com fibromialgia. O objetivo principal do estudo foi avaliar a eficácia de uma dose regular de 50 mg para fibromialgia.

Os resultados do estudo revelaram alguns dados interessantes. Os pacientes que receberam a dose regular de 50 mg para fibromialgia tiveram uma melhora significativa na qualidade do sono, na rigidez matinal e nos limiares de dor. O ‘score do tender point’ tirado na época não melhorou.

Novos estudos sobre o medicamento para pacientes com fibromialgia seguem a mais nova iteração dos critérios de fibromialgia. Uma complicação de dados de outros estudos sobre a medicação descobriu que ‘a amitriptilina para fibromialgia pode continuar a ser usada para o tratamento [da dor neuropática], mas a maioria dos pacientes não conseguirá alívio suficiente da dor.’

Vários estudos coletados na complicação duraram até 6 semanas (em média). Eles também testaram entre 15 a 100 participantes, com quatro dos estudos hospedando mais de 100 participantes. Cada estudo administrou doses entre 15 mg e 125 mg.

Alguns estudos aumentaram gradualmente a dose durante intervalos selecionados do estudo do estudo. No geral, nenhuma evidência concreta foi encontrada para apoiar a amitriptilina como um tratamento eficaz para a fibromialgia. Alguns estudos descobriram que ele pode desempenhar um papel na redução de algumas dores neuropáticas, como a dor associada à fibromialgia.

267 thoughts on “Como a amitriptilina pode ajudar as pessoas com fibromialgia

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